Blind mice are not impaired in T-maze footshock avoidance acquisition and retention.

摘要: Abstract The processing of visual information during learning and memory is considered to be a vital function the hippocampus. Some researchers believe that sole purpose hippocampus process visuo-spatial information, whereas other investigators integrates cues from multiple sources. In current studies, we tested effects vision loss on hippocampal task, acquisition retention with T-maze footshock avoidance conditioning. Acquisition retention, in adult-blinded mice, were not significantly impaired avoidance. Blindness did affect activity, startle or motivation avoid shock. same doses enhancing drugs improve sighted mice improved blind mice. Electrolytic lesions which destroyed 31±4% hippocampus, for so demonstrated retained its integrative role findings show are as capable retains important processing. It concluded conditioning task spatially but visually dependent hippocampally dependent.