Nonamnestic mild cognitive impairment progresses to dementia with Lewy bodies
作者： Tanis J Ferman , Glenn E Smith , Kejal Kantarci , Bradley F Boeve , V Shane Pankratz
DOI: 10.1212/01.WNL.0000436942.55281.47
关键词: Dementia with Lewy bodies 、 Amnesia 、 Internal medicine 、 Cohort study 、 Parkinsonism 、 Alzheimer's disease 、 Disease 、 Survival analysis 、 Psychology 、 Memory impairment 、 Psychiatry
摘要: Objective: To determine the rate of progression mild cognitive impairment (MCI) to dementia with Lewy bodies (DLB). Methods: We followed 337 patients MCI in Mayo Alzheimer9s Disease Research Center (range 2–12 years). Competing risks survival models were used examine rates clinically probable DLB and Alzheimer disease (AD). A subset underwent neuropathologic examination. Results: In this clinical cohort, 116 remained as MCI, while 49 progressed DLB, 162 AD, 10 other dementias. Among nonamnestic was 20 events per 100 person-years AD 1.6 person-years. amnestic 17 person-years, 1.5 88% those who developed baseline diagnosis included attention and/or visuospatial deficits. Those more likely have daytime sleepiness subtle parkinsonism. 99% group, memory impairment. Neuropathologic confirmation obtained 24 30 14 18 DLB. Conclusion: a sample, develop AD.
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Murray W. Johns, A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. ,vol. 14, pp. 540- 545 ,(1991) , 10.1093/SLEEP/14.6.540
Marshal F. Folstein, Susan E. Folstein, Paul R. McHugh, “Mini-mental state” Journal of Psychiatric Research. ,vol. 12, pp. 189- 198 ,(1975) , 10.1016/0022-3956(75)90026-6
Tanis J Ferman, Glenn E Smith, Bradley F Boeve, Neill R Graff-Radford, John A Lucas, David S Knopman, Ronald C Petersen, Robert J Ivnik, Zbigniew Wszolek, Ryan Uitti, Dennis W Dickson, None, Neuropsychological Differentiation of Dementia with Lewy Bodies from Normal Aging and Alzheimer's Disease The Clinical Neuropsychologist. ,vol. 20, pp. 623- 636 ,(2006) , 10.1080/13854040500376831
Hirotake Uchikado, Wen-Lang Lin, Michael W. DeLucia, Dennis W. Dickson, Alzheimer disease with amygdala lewy bodies : A distinct form of α-synucleinopathy Journal of Neuropathology and Experimental Neurology. ,vol. 65, pp. 685- 697 ,(2006) , 10.1097/01.JNEN.0000225908.90052.07
SM Landau, D Harvey, CM Madison, EM Reiman, NL Foster, PS Aisen, Ronald Carl Petersen, LM Shaw, JQ Trojanowski, CR Jack Jr, MW Weiner, WJ Jagust, None, Comparing predictors of conversion and decline in mild cognitive impairment Neurology. ,vol. 75, pp. 230- 238 ,(2010) , 10.1212/WNL.0B013E3181E8E8B8
Ronald C. Petersen, Rosebud O. Roberts, David S. Knopman, Bradley F. Boeve, Yonas E. Geda, Robert J. Ivnik, Glenn E. Smith, Clifford R. Jack, Mild cognitive impairment: ten years later. JAMA Neurology. ,vol. 66, pp. 1447- 1455 ,(2009) , 10.1001/ARCHNEUROL.2009.266
M. M. Machulda, R. J. Ivnik, G. E. Smith, T. J. Ferman, B. F. Boeve, D. Knopman, R. C. Petersen, E. G. Tangalos, Mayo's Older Americans Normative Studies: Visual Form Discrimination and copy trial of the Rey–Osterrieth Complex Figure Journal of Clinical and Experimental Neuropsychology. ,vol. 29, pp. 377- 384 ,(2007) , 10.1080/13803390600726803
D. Neary, J. S. Snowden, L. Gustafson, U. Passant, D. Stuss, S. Black, M. Freedman, A. Kertesz, P. H. Robert, M. Albert, K. Boone, B. L. Miller, J. Cummings, D. F. Benson, Frontotemporal lobar degeneration A consensus on clinical diagnostic criteria Neurology. ,vol. 51, pp. 1546- 1554 ,(1998) , 10.1212/WNL.51.6.1546
T. J. Ferman, G. E. Smith, B. F. Boeve, R. J. Ivnik, R. C. Petersen, D. Knopman, N. Graff-Radford, J. Parisi, D. W. Dickson, DLB fluctuations Specific features that reliably differentiate DLB from AD and normal aging Neurology. ,vol. 62, pp. 181- 187 ,(2004) , 10.1212/WNL.62.2.181
J. C. Morris, The Clinical Dementia Rating (CDR): Current version and scoring rules Neurology. ,vol. 43, pp. 2412- 2414 ,(1993) , 10.1212/WNL.43.11.2412-A