Pyridine and quinoline molecules as crucial protagonists in the never-stopping discovery of new agents against tuberculosis

摘要: Abstract Tuberculosis (TB) disease remains to be an alarming infection worldwide with nearly 1.6 million deaths per year ranking above HIV/AIDS. Although Mycobacterium tuberculosis (Mtb), which causes TB, was identified more than 130 years ago, nowadays only old vaccine (Bacillus Calmette-Guerin vaccine) and classical toxic drugs that are losing its effectiveness available in clinic practice. Despite enormous efforts drug research on TB treatment including vaccines diagnostics investigations, this contagious, infectious is still a major public health problem. The goal of elimination epidemic by 2035 will not achieved without combined strategies based faster diagnostic tools, effective drugs. In the field chemotherapy, novel molecular design new compounds able efficiently kill Mtb via disruption diverse biological targets evidently required. sense, pyridine quinoline stand out as promising molecules against drug-resistant tuberculosis. Indeed, many candidate heterocyclic skeletons currently being tested. Among them, derivatives like gatifloxacin, moxifloxacin bedaquiline (sirturo), such sudoterb agent BRD-8000.3 have been shown high potential for forms disease. work we review most significant advances discussing briefly their physicochemical parameters (descriptors) calculated Molinspiration software.