Introduction: metallopeptidases and their clans

摘要: Publisher Summary This chapter presents an introduction to metallopeptidases and their clans. Metallopeptidases are among the hydrolases in which nucleophilic attack on a peptide bond is mediated by water molecule. characteristic shared with aspartic peptidases; however, divalent metal cation, usually zinc but sometimes cobalt, manganese, nickel or copper activates The ion held place amino acid ligands, three number. can be divided into two broad groups depending number of ions required for catalysis. In many metallopeptidases, only one required, some families there that act together ‘co-catalytically.’ All cobalt manganese essential require ions, also zinc-dependent co-catalytic. peptidases containing ion, nonpeptidase homologs have co-catalytic ions. known ligands His, Glu, Asp Lys residues.