Older Anticonvulsants Continuing in Use but with Limited Advance in Knowledge

摘要: Several relatively long-established anticonvulsants continue in clinical use though there has been comparatively little advance knowledge of their pharmacologies. Whilst more effective and less toxic alternatives are now available, significant numbers patients to be satisfactorily managed with these older drugs they sometimes extremely helpful after modern counterparts prove inadequate. Such agents include phenobarbitone its congeners, the succinimides, sulthiame acetazolamide, bromides. The various oxazolidinediones (principally troxidone — trimetha-dione), formerly important for treating absence epilepsy, seem have almost completely disappeared from use, still employed experimental laboratory studies.