Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology

作者: Conor Mc Guire , Marco Prinz , Rudi Beyaert , Geert van Loo

DOI: 10.1016/J.MOLMED.2013.08.001

关键词: PathologyPathogenesisCentral nervous systemImmunologyMultiple sclerosisImmune systemInflammationExperimental autoimmune encephalomyelitisNF-κBTumor necrosis factor alphaMedicineMolecular medicineMolecular biology

摘要: … In addition, neuronal NF-κB protects against excitotoxic or … neurons, no constitutive NF-κB activity is detected in glial cells in unchallenged conditions, suggesting that inducible NF-κB …

参考文章(125)
Bruno Bonetti, Chiara Stegagno, Barbara Cannella, Nicola Rizzuto, Giuseppe Moretto, Cedric S. Raine, Activation of NF-κB and c-jun Transcription Factors in Multiple Sclerosis Lesions: Implications for Oligodendrocyte Pathology American Journal of Pathology. ,vol. 155, pp. 1433- 1438 ,(1999) , 10.1016/S0002-9440(10)65456-9
Heather A. Arnett, Jeff Mason, Mike Marino, Kinuko Suzuki, Glenn K. Matsushima, Jenny P.-Y. Ting, TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nature Neuroscience. ,vol. 4, pp. 1116- 1122 ,(2001) , 10.1038/NN738
Radiah A. Corn, Chris Hunter, Hsiou-Chi Liou, Ulrich Siebenlist, Mark R. Boothby, Opposing Roles for RelB and Bcl-3 in Regulation of T-Box Expressed in T Cells, GATA-3, and Th Effector Differentiation Journal of Immunology. ,vol. 175, pp. 2102- 2110 ,(2005) , 10.4049/JIMMUNOL.175.4.2102
Holm Schneider, Charles Coutelle, In utero gene therapy: the case for. Nature Medicine. ,vol. 5, pp. 256- 257 ,(1999) , 10.1038/6458
Armin Schneider, Ana Martin-Villalba, Falk Weih, Johannes Vogel, Thomas Wirth, Markus Schwaninger, NF-κB is activated and promotes cell death in focal cerebral ischemia Nature Medicine. ,vol. 5, pp. 554- 559 ,(1999) , 10.1038/8432
Beatrice Coornaert, Mathijs Baens, Karen Heyninck, Tine Bekaert, Mira Haegman, Jens Staal, Lijun Sun, Zhijian J Chen, Peter Marynen, Rudi Beyaert, T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20 Nature Immunology. ,vol. 9, pp. 263- 271 ,(2008) , 10.1038/NI1561
Jyoti Das, Chang-Hung Chen, Liyan Yang, Lauren Cohn, Prabir Ray, Anuradha Ray, A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nature Immunology. ,vol. 2, pp. 45- 50 ,(2001) , 10.1038/83158
Min-Jean Yin, Yumi Yamamoto, Richard B. Gaynor, The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β Nature. ,vol. 396, pp. 77- 80 ,(1998) , 10.1038/23948
Roberta Brambilla, Trikaldarshi Persaud, Xianchen Hu, Shaffiat Karmally, Valery I. Shestopalov, Galina Dvoriantchikova, Dmitry Ivanov, Lubov Nathanson, Scott R. Barnum, John R. Bethea, Transgenic Inhibition of Astroglial NF-κB Improves Functional Outcome in Experimental Autoimmune Encephalomyelitis by Suppressing Chronic Central Nervous System Inflammation Journal of Immunology. ,vol. 182, pp. 2628- 2640 ,(2009) , 10.4049/JIMMUNOL.0802954
Kris A. Steinbrecher, Eleana Harmel-Laws, Raquel Sitcheran, Albert S. Baldwin, Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation. Journal of Immunology. ,vol. 180, pp. 2588- 2599 ,(2008) , 10.4049/JIMMUNOL.180.4.2588