A pilot genome-wide association study of breast cancer susceptibility loci in Indonesia.
作者： Samuel J Haryono , I Gusti Bagus Datasena , Wahyu Budi Santosa , Raymond Mulyarahardja , Kartika Sari
DOI: 10.7314/APJCP.2015.16.6.2231
关键词: Genetic predisposition 、 Genetics 、 Odds ratio 、 Genome-wide association study 、 Biology 、 Single-nucleotide polymorphism 、 Genetic association 、 Allele 、 Breast cancer 、 Genotype
摘要: Abstract Genome-wide association studies (GWASs) of the entire genome provide a systematic approach for revealing novel genetic susceptibility loci breast cancer. However, have hitherto been primarily conducted in women European ancestry. Therefofre we here performed pilot GWAS with single nucleotide polymorphism (SNP) array 5.0 platform from Affymetrix® that contains 443,813 SNPs to search new risk factors 89 cancer cases and 46 healthy Indonesian The case-control finding set was evaluated using PLINK. strengths allelic genotypic associations were assessed logistic regression analysis reported as odds ratios (ORs) P values; values less than 1.00x10(-8) 5.00x10(-5) required significant suggestive association, respectively. After analyzing 292,887 SNPs, recognized 11 chromosome possessed risk. Of these, however, there only four identified genes: 2p.12 CTNNA2 gene [Odds ratio (OR)=1.20, 95% confidence interval (CI)=1.13-1.33, P=1.08x10(-7)]; 18p11.2 SOGA2 (OR=1.32, 95%CI=1.17-1.44, P=6.88x10(-6)); 5q14.1 SSBP2 (OR=1.22, 95%CI=1.11-1.34, P=4.00x10(-5)); 9q31.1 TEX10 (OR=1.24, 95%CI=1.12-1.35, P=4.68x10(-5)). This study which exhibited among women.
koreascience.or.kr参考文章(30)
Hiroshi Yoshitake, Hidenori Yokoi, Hitoshi Ishikawa, Mayuko Maruyama, Shuichiro Endo, Michio Nojima, Koyo Yoshida, Hiroshi Yoshikawa, Fujihiko Suzuki, Kenji Takamori, Hiroshi Fujiwara, Yoshihiko Araki, Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell carcinoma. Cancer Biomarkers. ,vol. 12, pp. 141- 148 ,(2013) , 10.3233/CBM-130302
Katherine N. Nathanson, Richard Wooster, Barbara L. Weber, Breast cancer genetics: what we know and what we need. Nature Medicine. ,vol. 7, pp. 552- 556 ,(2001) , 10.1038/87876
Kooshyar Mohammad Mahdi, Mohammad Reza Nassiri, Khadijeh Nasiri, None, Hereditary Genes and SNPs Associated with Breast Cancer Asian Pacific Journal of Cancer Prevention. ,vol. 14, pp. 3403- 3409 ,(2013) , 10.7314/APJCP.2013.14.6.3403
Allan Balmain, Joe Gray, Bruce Ponder, The genetics and genomics of cancer Nature Genetics. ,vol. 33, pp. 238- 244 ,(2003) , 10.1038/NG1107
Simon N Stacey, Andrei Manolescu, Patrick Sulem, Steinunn Thorlacius, Sigurjon A Gudjonsson, Gudbjörn F Jonsson, Margret Jakobsdottir, Jon T Bergthorsson, Julius Gudmundsson, Katja K Aben, Luc J Strobbe, Dorine W Swinkels, K C Anton van Engelenburg, Brian E Henderson, Laurence N Kolonel, Loic Le Marchand, Esther Millastre, Raquel Andres, Berta Saez, Julio Lambea, Javier Godino, Eduardo Polo, Alejandro Tres, Simone Picelli, Johanna Rantala, Sara Margolin, Thorvaldur Jonsson, Helgi Sigurdsson, Thora Jonsdottir, Jon Hrafnkelsson, Jakob Johannsson, Thorarinn Sveinsson, Gardar Myrdal, Hlynur Niels Grimsson, Steinunn G Sveinsdottir, Kristin Alexiusdottir, Jona Saemundsdottir, Asgeir Sigurdsson, Jelena Kostic, Larus Gudmundsson, Kristleifur Kristjansson, Gisli Masson, James D Fackenthal, Clement Adebamowo, Temidayo Ogundiran, Olufunmilayo I Olopade, Christopher A Haiman, Annika Lindblom, Jose I Mayordomo, Lambertus A Kiemeney, Jeffrey R Gulcher, Thorunn Rafnar, Unnur Thorsteinsdottir, Oskar T Johannsson, Augustine Kong, Kari Stefansson, Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer. Nature Genetics. ,vol. 40, pp. 703- 706 ,(2008) , 10.1038/NG.131
A Chandra, Node-positive breast cancers diagnosed in 2011 at York Teaching Hospitals NHS Trust: an analysis of the adequacy of current preoperative assessment Breast Cancer Research. ,vol. 14, pp. 56- ,(2012) , 10.1186/BCR3311
Douglas F Easton, Karen A Pooley, Alison M Dunning, Paul DP Pharoah, Deborah Thompson, Dennis G Ballinger, Jeffery P Struewing, Jonathan Morrison, Helen Field, Robert Luben, Nicholas Wareham, Shahana Ahmed, Catherine S Healey, Richard Bowman, SEARCH collaborators Luccarini Craig 61 Conroy Don 61 Shah Mitul 61 Munday Hannah 61 Jordan Clare 61 Perkins Barbara 61 West Judy 61 Redman Karen 61 Driver Kristy 61, Kerstin B Meyer, Christopher A Haiman, Laurence K Kolonel, Brian E Henderson, Loic Le Marchand, Paul Brennan, Suleeporn Sangrajrang, Valerie Gaborieau, Fabrice Odefrey, Chen-Yang Shen, Pei-Ei Wu, Hui-Chun Wang, Diana Eccles, D Gareth Evans, Julian Peto, Olivia Fletcher, Nichola Johnson, Sheila Seal, Michael R Stratton, Nazneen Rahman, Georgia Chenevix-Trench, Stig E Bojesen, Børge G Nordestgaard, Christen K Axelsson, Montserrat Garcia-Closas, Louise Brinton, Stephen Chanock, Jolanta Lissowska, Beata Peplonska, Heli Nevanlinna, Rainer Fagerholm, Hannaleena Eerola, Daehee Kang, Keun-Young Yoo, Dong-Young Noh, Sei-Hyun Ahn, David J Hunter, Susan E Hankinson, David G Cox, Per Hall, Sara Wedren, Jianjun Liu, Yen-Ling Low, Natalia Bogdanova, Peter Schürmann, Thilo Dörk, Rob AEM Tollenaar, Catharina E Jacobi, Peter Devilee, Jan GM Klijn, Alice J Sigurdson, Michele M Doody, Bruce H Alexander, Jinghui Zhang, Angela Cox, Ian W Brock, Gordon MacPherson, Malcolm WR Reed, Fergus J Couch, Ellen L Goode, Janet E Olson, Hanne Meijers-Heijboer, Ans van den Ouweland, André Uitterlinden, Fernando Rivadeneira, Roger L Milne, Gloria Ribas, Anna Gonzalez-Neira, Javier Benitez, John L Hopper, Margaret McCredie, Melissa Southey, Graham G Giles, Chris Schroen, Christina Justenhoven, Hiltrud Brauch, Ute Hamann, Yon-Dschun Ko, Amanda B Spurdle, Jonathan Beesley, Xiaoqing Chen, AOCS Management Group Bowtell David 146 Green Adele 82 deFazio Anna 147 Chenevix-Trench Georgia 82 Gertig Dorota 111 Webb Penny 82, Arto Mannermaa, Veli-Matti Kosma, Vesa Kataja, Jaana Hartikainen, Nicholas E Day, David R Cox, Bruce AJ Ponder, None, Genome-wide association study identifies novel breast cancer susceptibility loci Nature. ,vol. 447, pp. 1087- 1093 ,(2007) , 10.1038/NATURE05887
Wei Zheng, Jirong Long, Yu-Tang Gao, Chun Li, Ying Zheng, Yong-Bin Xiang, Wanqing Wen, Shawn Levy, Sandra L Deming, Jonathan L Haines, Kai Gu, Alecia Malin Fair, Qiuyin Cai, Wei Lu, Xiao-Ou Shu, Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1 Nature Genetics. ,vol. 41, pp. 324- 328 ,(2009) , 10.1038/NG.318
Robert Welch, Amy Hutchinson, Junwen Wang, Kai Yu, Nilanjan Chatterjee, Nick Orr, Walter C Willett, Graham A Colditz, Regina G Ziegler, Christine D Berg, Saundra S Buys, Catherine A McCarty, Heather Spencer Feigelson, Eugenia E Calle, Michael J Thun, Richard B Hayes, Margaret Tucker, Daniela S Gerhard, Joseph F Fraumeni, Robert N Hoover, Gilles Thomas, Stephen J Chanock, David J Hunter, Peter Kraft, Kevin B Jacobs, David G Cox, Meredith Yeager, Susan E Hankinson, Sholom Wacholder, Zhaoming Wang, A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer Nature Genetics. ,vol. 39, pp. 870- 874 ,(2007) , 10.1038/NG2075
Jirong Long, Qiuyin Cai, Xiao-Ou Shu, Shimian Qu, Chun Li, Ying Zheng, Kai Gu, Wenjing Wang, Yong-Bing Xiang, Jiarong Cheng, Kexin Chen, Lina Zhang, Hong Zheng, Chen-Yang Shen, Chiun-Sheng Huang, Ming-Feng Hou, Hongbing Shen, Zhibin Hu, Furu Wang, Sandra L Deming, Mark C Kelley, Martha J Shrubsole, Ui Soon Khoo, Kelvin YK Chan, Sum Yin Chan, Christopher A Haiman, Brian E Henderson, Loic Le Marchand, Motoki Iwasaki, Yoshio Kasuga, Shoichiro Tsugane, Keitaro Matsuo, Kazuo Tajima, Hiroji Iwata, Bo Huang, Jiajun Shi, Guoliang Li, Wanqing Wen, Yu-Tang Gao, Wei Lu, Wei Zheng, None, Identification of a Functional Genetic Variant at 16q12.1 for Breast Cancer Risk: Results from the Asia Breast Cancer Consortium PLoS Genetics. ,vol. 6, pp. e1001002- 9 ,(2010) , 10.1371/JOURNAL.PGEN.1001002