The polypeptides of hepatitis A virus.

作者: Anthony G. Coulepis , Stephen A. Locarnini , Allan A. Ferris , Noreen I. Lehmann , Ian D. Gust

DOI: 10.1159/000148964

关键词: HepatitisVirusVirologyHepatitis ABiologyMolecular massPicornaviridaeDifferential centrifugationHepatitis B virus DNA polymeraseUltracentrifuge

摘要: Hepatitis A virus was purified from fecal specimens obtained 3 patients with naturally acquired hepatitis A, by a process of differential centrifugation, chloroform extraction, column chromatography, and isopycnic ultracentrifugation. Analysis discontinuous SDS-PAGE revealed three major polypeptides molecular weights 34,000, 25,500, 23,000 daltons. These appear to be specific for have similar the four reported members genus Enterovirus within family Picornaviridae.

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