Stem cell injections in knee osteoarthritis: a systematic review of the literature

摘要: Objective Stem cell injection for knee osteoarthritis (KOA) is an emerging new therapy, and we aimed to review its evidence of efficacy. Design Systematic review. Eligibility criteria Criteria eligibility were randomised controlled trials (RCTs) non-RCT on the efficacy stem injections in KOA. All references checked missed articles. Data sources MEDLINE, EMBASE, CINAHL, Web Science, Cochrane Library, PEDro SPORTDiscus searched. A grey literature search was performed. No restrictions imposed our strategy. Risk bias data synthesis assessed using risk tool. Descriptive performed levels according Oxford Levels Evidence. Results Five RCTs one found. Bone-marrow-derived cells, adipose-derived mesenchymal cells peripheral blood used. at high bias, resulting level-3 evidence. five reported superior patient-reported outcomes (Visual Analogue Scale, Western Ontario McMaster Universities Arthritis Index, Tegner, Lysolm, International Knee Documentation Committee, Injury Osteoarthritis Outcome Score, Lequesne) compared with controls final follow-up (range 24–48 months). Superior radiological found favouring injection. histological and/or improved arthroscopically scored healing rates two trials. serious adverse events reported. Conclusion Six showed or level-4 favour In absence high-level evidence, do not recommend therapy