Infarct volume after glioblastoma surgery as an independent prognostic factor

摘要: // Stefanie Bette 1 , Benedikt Wiestler Johannes Kaesmacher Thomas Huber Julia Gerhardt 2 Melanie Barz Claire Delbridge 3 Yu-Mi Ryang Florian Ringel Claus Zimmer Bernhard Meyer Tobias Boeckh-Behrens Jan S. Kirschke Jens Gempt Department of Neuroradiology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany Neurosurgery, Neuropathology, Correspondence to: Bette, email: stefanie.bette@tum.de Keywords: glioblastoma, infarct volume, karnofsky performance score, overall survival Received: June 04, 2016      Accepted: July 29, Published: August 22, 2016 ABSTRACT Postoperative ischemia is associated with reduced functional independence measured by score (KPS), which correlates well survival. Other studies suggest that postoperative hypoxia might initiate infiltrative tumor growth. Therefore, aim this study was to analyze the impact volume on and progression free (PFS) glioblastoma patients. 251 patients surgery for a newly diagnosed (WHO IV) were retrospectively assessed. Pre- KPS, date death/last follow-up histopathological markers recorded. infarction manually segmented. A significant correlation KPS decrease ( P = 0.001) observed. Infarct showed 0.014), but not PFS 0.112) in univariate analysis. This effect increased subgroup near-total resection (> 90%) (overall survival: 0.006, PFS: 0.066). remained as an independent prognostic factor multivariate analysis (HR 1.013 [1.000–1.026], 0.042) including other factors (age, extent resection, KPS). significantly after surgery. Besides influence perioperative also have biology initiating growth therefore impaired