HLA associations with leukemia
作者： MM Bortin , J D'Amaro , FH Bach , AA Rimm , JJ van Rood
DOI: 10.1182/BLOOD.V70.1.227.227
关键词: Chronic myelogenous leukemia 、 Antigen 、 HLA-A 、 Leukemia 、 Relative risk 、 Hla association 、 Myelogenous 、 Medicine 、 Immunology 、 Human leukocyte antigen 、 Cell biology 、 Biochemistry 、 Hematology
摘要: Frequencies of 35 HLA A, B, C, and DR antigens were determined in 1,834 leukemic Caucasoids to evaluate possible associations between leukemia. In comparison with the frequencies published controls, frequency Cw3 was significantly higher patients acute lymphoblastic leukemia (relative risk = 2.64, P less than 0.0002), myelogenous 1.92, 0.0007), chronic 2.07, 0.002; values adjusted for multiple comparisons). The Cw4 elevated 2.01, 0.0003), 2.06, 2.14, 0.0008). Aw19 decreased 0.68, 0.01) 0.59, 0.005). None other 32 investigated had a statistically significant association data suggest that may be markers susceptibility genes, while marker
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