Indicators of Walking Speed in Rheumatoid Arthritis: Relative Influence of Articular, Psychosocial, and Body Composition Characteristics

摘要: Objective To explore the contributions from and interactions between articular swelling damage, psychosocial factors, body composition characteristics on walking speed in rheumatoid arthritis (RA). Methods RA patients underwent timed 400-meter long-corridor walk. Demographics, self-reported levels of depressive symptoms fatigue, RA characteristics, (using whole-body dual X-ray absorptiometry, abdominal thigh computed tomography) were assessed their associations with explored. Results A total 132 had data for walk, among whom 107 (81%) completed full 400 meters. Significant multivariable indicators slower older age, higher depression scores, reported pain swollen replaced joint counts, cumulative prednisone exposure, nontreatment disease-modifying antirheumatic drugs, worse composition. These features accounted 60% modeled variability speed. Among specific features, was primarily correlated large/medium lower-extremity involvement. However, these only 21% explainable Having any relevant characteristic associated a 20% lower those (P < 0.001), compared 6% better = 0.010 interaction). Conclusion Psychosocial factors are potentially reversible contributors to RA. Relative disease activity nonarticular collectively more potent an individual's mobility limitations.