Branched poly(lactide) synthesized by enzymatic polymerization: effects of molecular branches and stereochemistry on enzymatic degradation and alkaline hydrolysis.
作者： Keiji Numata , Rajiv K. Srivastava , Anna Finne-Wistrand , Ann-Christine Albertsson , Yoshiharu Doi
DOI: 10.1021/BM700537X
关键词: Hydrolysis 、 Polymer architecture 、 Molar mass distribution 、 Ring-opening polymerization 、 Organic chemistry 、 Polymer 、 Stereochemistry 、 Chemistry 、 Alkaline hydrolysis (body disposal) 、 Polymer chemistry 、 Lactide 、 Polymerization
摘要: In this article the effects of number molecular branches (chain ends) and stereochemistry poly(lactide)s (PLAs) on enzymatic degradation alkaline hydrolysis are studied. Various linear branched PLAs were synthesized using lipase PS (Pseudomonas fluorescens)-catalyzed ring-opening polymerization (ROP) lactide monomers having different stereochemistries (L-lactide, D-lactide, D,L-lactide). Five alcohols used as initiators for ROP, monomer-to-initiator molar feed ratio was varied from 10 to 100 1000 each branch in polymer architecture. The properties that would affect degradations, i.e., glass transition temperature, melting enthalpy, advancing contact angle, determined. PLA films degraded proteinase K or 1.0 M NaOH solution, weight loss changes average (Mn) studied during 12 h degradation. results suggest an increase enhances its degradability alkali hydrolyzability. Moreover, change Mn poly(L-lactide) (PLLA) by indicated decrease first place dependent thereafter length PLA. PLLA, poly(D-lactide) (PDLA), poly(D,L-lactide) (PDLLA) differed segment It is suggested PDLLA preferentially K.
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