Photoinduced Remote Functionalisations by Iminyl Radical Promoted C−C and C−H Bond Cleavage Cascades
作者： Elizabeth M. Dauncey , Sara P. Morcillo , James J. Douglas , Nadeem S. Sheikh , Daniele Leonori
关键词: Photochemistry 、 Bond cleavage 、 Molecule 、 Cleavage (embryo) 、 Photoredox catalysis 、 C h bond 、 Chemistry 、 Radical
摘要: A photoinduced cascade strategy leading to a variety of differentially functionalised nitriles and ketones has been developed. These reactions rely on the oxidative generation iminyl radicals from simple oximes. Radical transposition by C(sp3 )-(sp3 ) )-H bond cleavage gives access distal carbon that undergo SH 2 functionalisations. mild, visible-light-mediated procedures can be used for remote fluorination, chlorination, azidation, were applied modification bioactive structurally complex molecules.
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