Aptamer-Derived Peptides as Potent Inhibitors of the Oncogenic RhoGEF Tgat
作者： Nathalie Bouquier , Sylvie Fromont , Jean-Christophe Zeeh , Camille Auziol , Pauline Larrousse
DOI: 10.1016/J.CHEMBIOL.2009.02.006
关键词: Biology 、 RHOA 、 Peptide 、 Cell biology 、 Guanine nucleotide exchange factor 、 In vitro 、 Peptide library 、 Molecular biology 、 Peptide Metabolism 、 GTP' 、 Aptamer 、 Clinical biochemistry 、 Molecular medicine 、 Biochemistry 、 Pharmacology 、 Drug discovery 、 General Medicine
摘要: … that would target Tgat oncogenic activity, we first established whether the GEF activity of Tgat is involved in transformation. To do so, we designed a Tgat mutant, called Tgat L190E , …
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