Incorporation of Tenascin-C into the Extracellular Matrix by Periostin Underlies an Extracellular Meshwork Architecture

摘要: Extracellular matrix (ECM) underlies a complicated multicellular architecture that is subjected to significant forces from mechanical environment. Although various components of the ECM have been enumerated, mechanisms evolve sophisticated remain be addressed. Here we show periostin, matricellular protein, promotes incorporation tenascin-C into and organizes meshwork ECM. We found both periostin null mice exhibited similar phenotype, confined tibial periostitis, which possibly corresponds medial stress syndrome in human sports injuries. Periostin possessed adjacent domains bind other protein: fibronectin type I collagen, respectively. These functioned as bridge between ECM, increased deposition on The hexabrachions may stabilize bifurcations fibrils, integrated extracellular architecture. This study suggests role for adaptation