Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier.

作者: Yossi Gilgun-Sherki , Eldad Melamed , Daniel Offen

DOI: 10.1016/S0028-3908(01)00019-3

关键词: Blood–brain barrierNeuroprotectionAntioxidantReactive oxygen speciesBiochemistryExcitotoxicityGlutathionePharmacologyBiologyOxidative stressSuperoxide dismutase

摘要: … However, since our endogenous antioxidant defenses are not … the pathology following head trauma or other pathological states … different from those in other organs. The concentration of …

参考文章(147)
Lester Packer, Hans J. Tritschler, Klaus Wessel, Neuroprotection by the Metabolic Antioxidant α-Lipoic Acid Free Radical Biology and Medicine. ,vol. 22, pp. 359- 378 ,(1997) , 10.1016/S0891-5849(96)00269-9
Anders Kalén, Eeva-Liisa Appelkvist, Gustav Dallner, Age-related changes in the lipid compositions of rat and human tissues Lipids. ,vol. 24, pp. 579- 584 ,(1989) , 10.1007/BF02535072
Robert S. Pinals, Stanley B. Kaplan, Jeffrey G. Lawson, Bonnie Hepburn, A double‐blind, placebo‐controlled trial Arthritis & Rheumatism. ,vol. 29, pp. 1427- 1434 ,(1986) , 10.1002/ART.1780291202
Daniel Offen, Svetlana Gorodin, Eldad Melamed, Judith Hanania, Zvi Malik, Dopamine-melanin is actively phagocytized by PC12 cells and cerebellar granular cells: possible implications for the etiology of Parkinson's disease. Neuroscience Letters. ,vol. 260, pp. 101- 104 ,(1999) , 10.1016/S0304-3940(98)00950-1
Patrik Forsmark-Andrée, C.-P Lee, Gustav Dallner, Lars Ernster, Lipid peroxidation and changes in the ubiquinone content and the respiratory chain enzymes of submitochondrial particles Free Radical Biology and Medicine. ,vol. 22, pp. 391- 400 ,(1997) , 10.1016/S0891-5849(96)00330-9
M Flint Beal, Mitochondria, free radicals, and neurodegeneration. Current Opinion in Neurobiology. ,vol. 6, pp. 661- 666 ,(1996) , 10.1016/S0959-4388(96)80100-0
Byung K Jin, Dong Y Shin, Mi Y Jeong, Mi R Gwag, Haing W Baik, Kyung S Yoon, Yong H Cho, Wan S Joo, Yong S Kim, Hyung H Baik, Melatonin protects nigral dopaminergic neurons from 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity in rats Neuroscience Letters. ,vol. 245, pp. 61- 64 ,(1998) , 10.1016/S0304-3940(98)00170-0
S Stoll, H Hartmann, SA Cohen, WE Müller, None, The potent free radical scavenger α-lipoic acid improves memory in aged mice: Putative relationship to NMDA receptor deficits Pharmacology, Biochemistry and Behavior. ,vol. 46, pp. 799- 805 ,(1993) , 10.1016/0091-3057(93)90204-7
James S Goodwin, Jean M Goodwin, Philip J Garry, Association between nutritional status and cognitive functioning in a healthy elderly population JAMA: The Journal of the American Medical Association. ,vol. 249, pp. 2917- 2921 ,(1983) , 10.1001/JAMA.249.21.2917