The Hidden Conundrum of Phosphoinositide Signaling in Cancer
作者： Narendra Thapa , Xiaojun Tan , Suyong Choi , Paul F. Lambert , Alan C. Rapraeger
DOI: 10.1016/J.TRECAN.2016.05.009
关键词: Phosphatidylinositol 、 Kinase 、 PI3K/AKT/mTOR pathway 、 Cell biology 、 Pi 、 Protein kinase B 、 Cytoskeleton 、 Chemistry 、 mTORC1 、 Phospholipase C
摘要: Phosphoinositide 3-kinase (PI3K) generation of PI(3,4,5)P 3 from PI(4,5)P 2 and the subsequent activation Akt its downstream signaling cascades (e.g., mTORC1) dominate landscape phosphoinositide axis in cancer research. However, is breaking boundary as merely a substrate for PI3K phospholipase C (PLC) now an established lipid messenger pivotal various cellular events cancer. Here we review cancer, giving due weight to generating enzymes, phosphatidylinositol (PI) phosphate (PIP) kinases (PIPKs). We highlight how PIPKs serve proximal node interaction with cytoskeletal proteins regulates migratory invasive nexus metastasizing tumor cells.
sci-hub.se 参考文章(87)
Timothy A Yap, Lynn Bjerke, Paul A Clarke, Paul Workman, Drugging PI3K in cancer: refining targets and therapeutic strategies. Current Opinion in Pharmacology. ,vol. 23, pp. 98- 107 ,(2015) , 10.1016/J.COPH.2015.05.016
G.H. Jenkins, P.L. Fisette, R.A. Anderson, Type I Phosphatidylinositol 4-phosphate 5-kinase Isoforms Are Specifically Stimulated by Phosphatidic Acid Journal of Biological Chemistry. ,vol. 269, pp. 11547- 11554 ,(1994) , 10.1016/S0021-9258(19)78159-9
F. Shibasaki, Y. Homma, T. Takenawa, TWO TYPES OF PHOSPHATIDYLINOSITOL 3-KINASE FROM BOVINE THYMUS : MONOMER AND HETERODIMER FORM Journal of Biological Chemistry. ,vol. 266, pp. 8108- 8114 ,(1991) , 10.1016/S0021-9258(18)92948-0
Mabel R. Hokin, Lowell E. Hokin, ENZYME SECRETION AND THE INCORPORATION OF P32 INTO PHOSPHOLIPIDES OF PANCREAS SLICES Journal of Biological Chemistry. ,vol. 203, pp. 967- 977 ,(1953) , 10.1016/S0021-9258(19)52367-5
C L Carpenter, B C Duckworth, K R Auger, B Cohen, B S Schaffhausen, L C Cantley, Purification and characterization of phosphoinositide 3-kinase from rat liver. Journal of Biological Chemistry. ,vol. 265, pp. 19704- 19711 ,(1990) , 10.1016/S0021-9258(17)45429-9
Walter Kolch, Melinda Halasz, Marina Granovskaya, Boris N. Kholodenko, The dynamic control of signal transduction networks in cancer cells Nature Reviews Cancer. ,vol. 15, pp. 515- 527 ,(2015) , 10.1038/NRC3983
Elisa Zanardi, Giacomo Bregni, Filippo de Braud, Serena Di Cosimo, Better Together: Targeted Combination Therapies in Breast Cancer Seminars in Oncology. ,vol. 42, pp. 887- 895 ,(2015) , 10.1053/J.SEMINONCOL.2015.09.029
Li Zhang, Yuntao S. Mao, Paul A. Janmey, Helen L. Yin, Phosphatidylinositol 4, 5 Bisphosphate and the Actin Cytoskeleton Sub-cellular biochemistry. ,vol. 59, pp. 177- 215 ,(2012) , 10.1007/978-94-007-3015-1_6
Arpita Shah, Abhishek Mangaonkar, Idelalisib A Novel PI3Kδ Inhibitor for Chronic Lymphocytic Leukemia Annals of Pharmacotherapy. ,vol. 49, pp. 1162- 1170 ,(2015) , 10.1177/1060028015594813
Edwin A. Clark, Todd R. Golub, Eric S. Lander, Richard O. Hynes, Genomic analysis of metastasis reveals an essential role for RhoC Nature. ,vol. 406, pp. 532- 535 ,(2000) , 10.1038/35020106