NDN and CD1A are novel prognostic methylation markers in patients with head and neck squamous carcinomas
作者： Shama Virani , Emily Bellile , Carol R. Bradford , Thomas E. Carey , Douglas B. Chepeha
DOI: 10.1186/S12885-015-1806-8
关键词: Methylation 、 Oncology 、 Head and neck cancer 、 Candidate gene 、 GADD45A 、 Medicine 、 Cohort 、 Surgical oncology 、 DNA methylation 、 Internal medicine 、 Epigenetics
摘要: Background HPV-associated HNSCCs have a distinct etiologic mechanism and better prognosis than those with non-HPV associated HNSCCs. However, even within the each group, there is heterogeneity in survival time. Here, we test hypothesis that specific candidate gene methylation markers (CCNA1, NDN, CD1A, DCC, p16, GADD45A) are tumor recurrence survival, well-characterized, prospective, cohort of 346 HNSCC patients.
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