Exercise Training Reduces Cardiac Dysfunction and Remodeling in Ovariectomized Rats Submitted to Myocardial Infarction

摘要: The aim of this study was to evaluate whether exercise training (ET) prevents or minimizes cardiac dysfunction and pathological ventricular remodeling in ovariectomized rats subjected myocardial infarction (MI) examine the possible mechanisms involved process. Ovariectomized Wistar were either MI fictitious surgery (Sham) randomly divided into following groups: Control, OVX+SHAMSED, OVX+SHAMET, OVX+MISED OVX+MIET. ET performed on a motorized treadmill (5x/wk, 60 min/day, 8 weeks). Cardiac function assessed by catheterization Dihydroethidium fluorescence (DHE) evaluated analyze oxidative stress. Histological analyses made assess collagen deposition, myocyte hypertrophy infarct size. Western Blotting protein expression catalase SOD-2, as well Gp91phox AT1 receptor (AT1R). MI-trained had significantly increased +dP/dt decreased left end-diastolic pressure compared with MI-sedentary rats. Moreover, stress deposition reduced, hypertrophy. These effects occurred parallel reduction both AT1R an increase expression. SOD-2 not altered. results indicate that improves functional parameters associated attenuation MI. mechanism seems be related antioxidant enzyme catalase, which contributes Therefore, may important therapeutic target for prevention heart failure postmenopausal women affected