CIRCULAR RNA COMPOSITIONS AND METHODS
作者： Goodman Brian , Squilloni Raffaella , Horhota Allen , Fuse Shinichiro , Wesselhoeft Alexander
DOI:
关键词: Chemistry 、 Circular RNA 、 Duplex (building) 、 Immunogenicity 、 Internal ribosome entry site 、 Functional stability 、 RNA splicing 、 RNA 、 Computational biology 、 Intron
摘要: Circular RNA and transfer vehicles, along with related compositions methods are described herein. In some embodiments, the inventive circular comprises group I intron fragments, spacers, an IRES, duplex forming regions, expression sequence. sequence encodes a chimeric antigen receptor (CAR). of invention has improved expression, functional stability, immunogenicity, ease manufacturing, and/or half-life when compared to linear RNA. constructs result in circularization efficiency, splicing purity existing approaches.
lens.org 参考文章(67)
Jefferson Foote, Method of humanizing antibodies by matching canonical structure types CDRs ,(2006)
Nelson S. Yew, Robin J. Ziegler, Seng H. Cheng, Compositions and methods for treating lysosomal storage disease ,(1998)
Nelson Yew, Robin Ziegler, Chester Li, Seng Cheng, Genetic modification of the lung as a portal for gene delivery ,(2001)
Kenneth R. Sidman, Biodegradable, implantable drug delivery depots, and method for preparing and using the same ,(1981)
Vasant Jadhav, Chandra Vargeese, Lucinda Shaw, Kristi Jensen, David Morrissey, Compositions and methods for potentiated activity of biologicaly active molecules ,(2008)
James Swarbrick, Anya M Hillery, Andrew W Lloyd, Drug Delivery and Targeting : For Pharmacists and Pharmaceutical Scientists ,(2001)
John S. Kent, Cholesterol matrix delivery system for sustained release of macromolecules ,(1982)
Nancy W. Harman, Geng Lin, Branched polyether-polyamide block copolymers and methods of making and using the same ,(2012)
Vladimir G. Budker, James E. Hagstrom, Jeffery Fritz, Jon A. Wolff, Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein ,(1998)
Andre E. Myers, Daniel Bichon, Cytotoxic drug conjugates and their delivery to tumor cells ,(1987)