Effects of Soluble Epoxide Hydrolase Deficiency on Acute Pancreatitis in Mice

摘要: Background Acute pancreatitis (AP) is a frequent gastrointestinal disorder that causes significant morbidity, and its incidence has been progressively increasing. AP starts as local inflammation in the pancreas often leads to systemic inflammatory response complications. Soluble epoxide hydrolase (sEH) cytosolic enzyme whose inhibition murine models beneficial effects diseases, but significance remains unexplored. Methodology/Principal Findings To investigate whether sEH may have causal role we utilized Ephx2 knockout (KO) mice determine of deficiency on cerulein- arginine-induced AP. expression increased at protein messenger RNA levels, well enzymatic activity early phase mice. In addition, amylase lipase levels were lower cerulein-treated KO compared with controls. Moreover, pancreatic mRNA serum concentrations cytokines IL-1B IL-6 Further, exhibited decreased NF-κB response, MAPKs activation cell death. Conclusions -These findings demonstrate novel for progression