作者: Landais P , Goldfarb B , Kleinknecht D
DOI:
关键词: Medicine 、 Nephrology 、 Renal biopsy 、 Resuscitation 、 Renal function 、 Surgery 、 Gastroenterology 、 Internal medicine 、 Oliguria 、 Glafenine 、 Acute tubular necrosis 、 Interstitial nephritis
摘要: During a one-year period, drug-associated acute renal failure (ARF) was prospectively recorded in 398 patients, registered 58 french nephrology Units. Drugs involved were primarily antibiotics, mainly aminoglycosides, glafenine, non-steroidal antiinflammatory drugs and contrast media. Hypersensitivity reactions reported 69 patients. Renal biopsy, performed 81 instances, showed tubular necrosis 42 interstitial nephritis 20 Hypotension, sodium depletion and/or cardiac predisposing factors 198 cases. Fifty patients died, 251 recovered fully or regained previous function, 93 permanent damage remained. Advanced age, oliguria, severe ARF, preexisting cardiac, hepatic insufficiency poor prognostic factors. Prevention of ARF should be directed to high-risk particularly those receiving aminoglycosides