Development of a novel AIDS vaccine: the HIV-1 transactivator of transcription protein vaccine

摘要: Introduction: Classical approaches aimed at targeting the HIV-1 envelope as well other structural viral proteins have largely failed. The transactivator of transcription (Tat) is a key HIV virulence factor, which plays pivotal roles in virus gene expression, replication, transmission and disease progression. Notably, anti-Tat Abs are uncommon natural infection and, when present, correlate with asymptomatic state lead to lower or no Hence, Tat represents pathogenesis-driven intervention.Areas covered: Here, we review rationale translational development therapeutic vaccine protein. Preclinical Phase I studies, II trials Ab-negative, virologically suppressed highly active antiretroviral therapy-treated subjects Italy South Africa were conducted. results indicate that Tat-induced immune responses necessary restore homeostasis, block replenishment reduce ...