A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines
作者： Felicia Phei Lin Lim , Lin Yuing Tan , Edward R. T. Tiekink , Anton V. Dolzhenko
DOI: 10.1039/C8RA03703E
关键词: Crystal structure 、 Cyanamide 、 Combinatorial chemistry 、 Materials science 、 Highly selective 、 Microwave irradiation 、 Alkyl 、 Molecule
摘要: A highly selective, one-pot, three-component synthesis of novel 2-alkyl-substituted 4-aminoimidazo[1,2-a][1,3,5]triazines has been developed. The scope the method was explored in two dimensions, varying structures trialkyl orthoesters and 2-aminoimidazoles their reactions with cyanamide. Conveniently performed under microwave irradiation, this also proved to be efficient conventional heating. library 24 compounds prepared high purity using multicomponent approach. Molecular crystal representative molecules were studied X-ray crystallography.
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