Vasorelaxant effect of Prunus yedoensis bark

摘要: Prunus yedoensis Matsum. is used as traditional medicine—‘Yaeng-Pi’ or ‘Hua-Pi’—in Japan and Korea. However, no studies have examined the pharmacological activities of P. bark. Only antioxidant antiviral fruit anti-hyperglycaemic effect leaf been investigated. While studying antihypertensive effects several medicinal plants, we found that a methanol extract bark (MEPY) had distinct vasorelaxant on rat aortic rings. The rings were removed from Sprague–Dawley rats suspended in organ chambers containing 10 ml Krebs-Henseleit solution. placed between 2 tungsten stirrups connected to an isometric force transducer. Changes tension recorded via transducers data acquisition system. MEPY relaxed contraction induced by phenylephrine (PE) both endothelium-intact endothelium-denuded concentration dependently. lower than reduced pre-treatment with l-NAME, methylene blue, ODQ. indomethacin, atropine, glibenclamide, tetraethylammonium, 4-aminopyridine affection. In addition, inhibited extracellular Ca2+ thoracic aorta pre-contracted PE (1 μM) KCl (60 mM) Ca2+-free Our results suggest exerts its activation NO formation means l-Arg NO-cGMP pathways blockage channels.