An injectable and self-healing hydrogel for spatiotemporal protein release via fragmentation after passing through needles.
作者： Ik Sung Cho , Tooru Ooya
DOI: 10.1080/09205063.2017.1405573
关键词: Bovine serum albumin 、 Self-healing hydrogels 、 Needle size 、 Delivery system 、 Fragmentation (cell biology) 、 Dextran 、 Nanotechnology 、 Chemical engineering 、 Materials science 、 Self-healing 、 Kinetics
摘要: A dynamic hydrogel formulated by mixing a glycol chitosan (GC) and an oxidized dextran (Odex) were studied for protein-controlled release in conjunction with the fragmentation. series of injectable hydrogels derived from GC Odex upon simple without addition chemical crosslinking agents. The gelation readily took place at physiological pH temperature. influence concentration on time, mechanical properties, water content, vitro degradation investigated. Odex/GC showed good self-healing ability under conditions kept Schiff-base linkage over 2 wt %. kinetics model protein (bovine serum albumin) was found to be controlled changing needle size injection, attributed modulation apparent shape fragmented even self-healed state. Therefore, GC-based are expected promising platform delivery system various biomedical applications.
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