Association of obesity with worse disease severity in rheumatoid arthritis as well as with comorbidities: A long-term followup from disease onset

摘要: Objective To determine the association of obesity, defined as a body mass index (BMI) ≥30 or ≥28 kg/m2 by waist circumference (WC), with disease activity and severity, well its relationship to comorbidities in rheumatoid arthritis (RA). Methods The study population comprised 1,596 patients early RA (mean ± SD age 55.6 14.6 years, 67.8% women) who had been included Better Anti-Rheumatic Farmacotherapy observational from 1992–2006. In 2010, data on lifestyle factors were collected through postal questionnaire, answered 1,391 patients. Clinical outcomes Disease Activity Score 28 joints, sustained remission, physical function (Health Assessment Questionnaire [HAQ]), pain global health assessed visual analog scale, predefined comorbidities. Results After mean 9.5 3.7 BMI increased 25.4 4.2 26.0 4.5 (P = 0.000). The prevalence was 12.9% at baseline 15.8% followup. multivariable regression, kg/m2, both inclusion time survey independently associated higher activity, fewer HAQ score, more pain, worse general health. Also, obesity conferred odds for being diagnosed hypertension, diabetes mellitus, chronic pulmonary disease. Further, WC angina pectoris/acute myocardial infarction/coronary revascularization. contrast, none examined variables stroke transient ischemic attack. Lifestyle changes during period, such quitting smoking diet change, no impact outcomes. Conclusion Obesity comorbidities. Body measurements are recommended improve prediction course.