作者: Krysten W. Bold , Lisa M. Fucito , Kelly S. DeMartini , Robert F. Leeman , Henry R. Kranzler
DOI: 10.1016/J.DRUGALCDEP.2016.10.035
关键词: Affect (psychology) 、 Psychology 、 Impulsivity 、 Environmental health 、 Psychiatry 、 Naltrexone 、 Placebo 、 Trait 、 Mood 、 Young adult 、 Intervention (counseling)
摘要: Abstract Background Young adults with higher trait urgency (i.e., a tendency to act rashly in response heightened affect) may be especially vulnerable heavy drinking. The current study examined 1) the influence of on daily relations between affect and drinking intoxication, 2) whether influenced effectiveness naltrexone (vs. placebo) for reducing alcohol use. Methods This is secondary analysis data from 126 (n = 40 female) young adults, ages 18–25, enrolled double-blind, 8-week clinical trial comparing brief motivational intervention either or placebo. Multilevel models moderated positive negative measured by an estimated blood-alcohol concentration (eBAC) at above legal limit (≥0.08 g%). Person-level interactions was more effective than placebo odds eBAC ≥ 0.08 g% individuals vs. lower urgency. Results On days greater within-person affect, were likely drink intoxication those Naltrexone reduced significantly placebo, independent Conclusions Although treatment overall, still increased risk hazardous following times strong mood. Targeted interventions are needed reduce among high