Cutting edge: polymorphisms in the ICOS promoter region are associated with allergic sensitization and Th2 cytokine production.
作者： Rebecca A. Shilling , Jayant M. Pinto , Donna C. Decker , Daniel H. Schneider , Hozefa S. Bandukwala
DOI: 10.4049/JIMMUNOL.175.4.2061
关键词: Allergy 、 Promoter 、 Asthma 、 Immunology 、 Biology 、 Allergic sensitization 、 Peripheral blood mononuclear cell 、 Regulator 、 Effector 、 Locus (genetics)
摘要: The establishment of ICOS as an important regulator Th2 development and effector function makes the locus attractive candidate for Th2-mediated diseases, such asthma allergy. In evaluation this in humans, we identified 11 variants determined that two putative promoter region are significantly associated with allergic sensitization serum IgE levels. addition, cultures activated PBMCs from individuals homozygous polymorphisms produced increased levels cytokines, IL-4, IL-5, IL-13, well TNF-α compared controls. One polymorphisms, −1413G/A, demonstrated differential NF-κB binding mobility shift analysis, suggesting polymorphism has functional consequences. Overall, these data demonstrate is a susceptibility gene sensitization, perhaps through promotion differentiation.
sci-hub.se 参考文章(30)
Chen Dong, Amy E. Juedes, Ulla-Angela Temann, Sujan Shresta, James P. Allison, Nancy H. Ruddle, Richard A. Flavell, ICOS co-stimulatory receptor is essential for T-cell activation and function Nature. ,vol. 409, pp. 97- 101 ,(2001) , 10.1038/35051100
Jose Angel Gonzalo, Jane Tian, Tracy Delaney, Justin Corcoran, James B. Rottman, Jose Lora, Amal Al-garawi, Richard Kroczek, Jose Carlos Gutierrez-Ramos, Anthony J. Coyle, ICOS is critical for T helper cell–mediated lung mucosal inflammatory responses Nature Immunology. ,vol. 2, pp. 597- 604 ,(2001) , 10.1038/89739
Anna Tafuri, Arda Shahinian, Friedhelm Bladt, Steve K. Yoshinaga, Manel Jordana, Andrew Wakeham, Louis-Martin Boucher, Denis Bouchard, Vera S. F. Chan, Gordon Duncan, Bernhard Odermatt, Alexandra Ho, Annick Itie, Tom Horan, John S. Whoriskey, Tony Pawson, Josef M. Penninger, Pamela S. Ohashi, Tak W. Mak, ICOS is essential for effective T-helper-cell responses. Nature. ,vol. 409, pp. 105- 109 ,(2001) , 10.1038/35051113
Andreas Hutloff, Anna M. Dittrich, Katja C. Beier, Barbara Eljaschewitsch, Regine Kraft, Ionnis Anagnostopoulos, Richard A. Kroczek, ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28 Nature. ,vol. 397, pp. 263- 266 ,(1999) , 10.1038/16717
Alexander J. McAdam, Rebecca J. Greenwald, Michele A. Levin, Tatyana Chernova, Nelly Malenkovich, Vincent Ling, Gordon J. Freeman, Arlene H. Sharpe, ICOS is critical for CD40-mediated antibody class switching Nature. ,vol. 409, pp. 102- 105 ,(2001) , 10.1038/35051107
Linda S. Wicker, Giselle Chamberlain, Kara Hunter, Dan Rainbow, Sarah Howlett, Paul Tiffen, Jan Clark, Andrea Gonzalez-Munoz, Anne Marie Cumiskey, Raymond L. Rosa, Joanna M. Howson, Luc J. Smink, Amanda Kingsnorth, Paul A. Lyons, Simon Gregory, Jane Rogers, John A. Todd, Laurence B. Peterson, Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse. Journal of Immunology. ,vol. 173, pp. 164- 173 ,(2004) , 10.4049/JIMMUNOL.173.1.164
Amanda G. Tesciuba, Sumit Subudhi, Russell P. Rother, Susan J. Faas, Aric M. Frantz, David Elliot, Joel Weinstock, Louis A. Matis, Jeffrey A. Bluestone, Anne I. Sperling, Inducible costimulator regulates Th2-mediated inflammation, but not Th2 differentiation, in a model of allergic airway disease Journal of Immunology. ,vol. 167, pp. 1996- 2003 ,(2001) , 10.4049/JIMMUNOL.167.4.1996
Kazuhiro Kikuchi, Yoshiki Yanagawa, Toshimasa Aranami, Chikako Iwabuchi, Kazuya Iwabuchi, Kazunori Onoe, Tumour necrosis factor-α but not lipopolysaccharide enhances preference of murine dendritic cells for Th2 differentiation Immunology. ,vol. 108, pp. 42- 49 ,(2003) , 10.1046/J.1365-2567.2003.01537.X
Vincent Ling, Paul W. Wu, Heather F. Finnerty, Michael J. Agostino, James R. Graham, Sanjun Chen, Jason M. Jussiff, Gregory J. Fisk, Christopher P. Miller, Mary Collins, Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches. Genomics. ,vol. 78, pp. 155- 168 ,(2001) , 10.1006/GENO.2001.6655
Kenji Ihara, Saifuddin Ahmed, Futoshi Nakao, Naoko Kinukawa, Ryuichi Kuromaru, Nobuo Matsuura, Isao Iwata, Seiho Nagafuchi, Hitoshi Kohno, Kenichi Miyako, Toshiro Hara, Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with type 1 diabetes in the Japanese population. Immunogenetics. ,vol. 53, pp. 447- 454 ,(2001) , 10.1007/S002510100351