Linked CD4 T Cell Help: Broadening Immune Attack Against Cancer by Vaccination

摘要: In the last decade, immunotherapy with monoclonal antibodies targeting immunological check points has become a breakthrough therapeutic modality for solid cancers. However, only up to 50 % of patients benefit from this powerful approach. For others vaccination might provide plausible addition or alternative. induction effective anticancer immunity CD4+ T cell help is required, which often difficult induce self cancer targets because tolerogenic mechanisms. Our approach vaccines been incorporate into vaccine design sequences able activate foreign help, through genetically linking microbial (King et al. in Nat Med 4(11):1281–1286, 1998; Savelyeva Biotechnol 19(8):760–764, 2001). This harnesses non-tolerized CD4 repertoire available against fused antigens. Multiple immune effector mechanisms including antibody, CD8+ cells as well can be activated using strategy. Delivery via DNA already indicated clinical efficacy. The same principle linked now transferred other novel modalities further potentiate targets.