Immune Compromise Associated with Biologics

摘要: Biologics are large molecule therapeutics, usually proteins, which isolated from human (or sometimes other biological) material, or produced by in vitro cell culture and recombinant gene technology. Many biologics specifically bind cellular soluble components of the immune system with very high avidity. The majority these themselves monoclonal antibodies. They generally highly effective depleting neutralizing their intended target. While this therapeutic precision can be valuable for treating diseases system, it also results a profound degree deficiency function targeted element, somewhat analogous to what is seen complete genetic deletion PID. Consequently, treated patient may lose ability control infections bacteria, fungi, protozoa, viruses, including those that cause neoplasms. Thus, compromise biologic therapy represents major clinical concern, limitation on development use agents.