Indoxyl sulfate exacerbates low bone turnover induced by parathyroidectomy in young adult rats
作者： Junya Hirata , Kazuya Hirai , Hirobumi Asai , Chiho Matsumoto , Masaki Inada
DOI: 10.1016/J.BONE.2015.06.010
关键词: Femur 、 Bone disease 、 Pathogenesis 、 Bone mineral 、 Parathyroidectomy 、 Chemistry 、 Endocrinology 、 Parathyroid hormone 、 Bone remodeling 、 Kidney disease 、 Internal medicine
摘要: Abstract Low-turnover bone disease is one of the abnormalities observed in patients with chronic kidney (CKD) and recognized to be associated low serum parathyroid hormone (PTH) level skeletal resistance PTH. Indoxyl sulfate (IS) a representative uremic toxin that accumulates blood as renal dysfunction progresses CKD patients. A recent vitro study using an osteoblastic cell culture system suggests IS has important role pathogenesis turnover through induction However, effects on progression have not been elucidated. In present study, we produced rats by performing parathyroidectomy (PTX) fed these diet containing indole, precursor IS, elevate from indole metabolism. Bone metabolism was evaluated measuring histomorphometric parameters secondary spongiosa femur. Histomorphometric analyses revealed significant decreases both formation–related resorption–related PTX rats. indole-treated rats, further were observed. addition, alkaline phosphatase activity, formation marker, mineral density tibia tended decrease These findings strongly suggest exacerbates inhibition mechanisms unrelated
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