Multitasking Roles for Poly(ADP-ribosyl)ation in Aging and Longevity
作者： Aswin Mangerich , Alexander Bürkle
DOI: 10.1007/978-3-319-14151-0_6
关键词: Epigenetics 、 DNA repair 、 Chromatin remodeling 、 Cell biology 、 Proteostasis 、 Proteome 、 Biology 、 Poly ADP ribose polymerase 、 Genome instability 、 Senescence
摘要: Aging is a multifactorial process that depends on diverse molecular and cellular mechanisms, such as genome instability, epigenetic transcriptional changes, loss of proteostasis, cell death senescence, metabolic dysfunction, inflammation. Enzymes the family poly(ADP-ribose) polymerases (PARPs) catalyze synthesis biopolymer (PAR), drastic post-translational modification plays significant roles in all these processes. On one hand, poly(ADP-ribosyl)ation (PARylation) contributes to proteome homeostasis, it participates chromatin remodeling, maintenance, cycle control, regulation ubiquitin-proteasome system. other PARPs PARylation interfere with organismic energy metabolism, act mediators inflammation, senescence death. Therefore, discussed both longevity assurance factor hand an aging-promoting hand. Here we highlight mechanisms underlying various aging focus mechanisms.
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