Extrarenal atherosclerotic disease blunts renal recovery in patients with renovascular hypertension.

摘要: Background Atherosclerotic renovascular disease (ARVD) is associated with high rates of coronary events and predicts mortality among patients artery (CAD). However, the impact atherosclerosis on renal outcomes after revascularization ARVD unclear. We hypothesized that CAD negatively impacts functional undergoing revascularization. Methods Patients who underwent echocardiography at Mayo Clinic, Rochester, Minnesota, USA between 2004 2012 were identified retrospectively included if they had ejection fraction more than 50%. Renal overall compared atherosclerotic (ARVD-C, n = 75) without (ARVD, 56), within 1 year from initial blood pressure control, function, incident cardiovascular/cerebrovascular events. Results Degree stenosis was similar in both groups. ARVD-C higher prevalence diabetes, peripheral (PAD), cerebrovascular disease, lower baseline function. Risk developing end-stage (11 vs. 2%, P 0.05). Despite better control cholesterol levels, function postrevascularization worsened 15% 2% (P 0.01). Differences clinical remained statistically significant adjustment for covariables, including sex, pressure, underlying medications. Similar differences also PAD disease. Conclusion a predictor worse revascularization, likely reflecting diffuse Further studies are needed to develop strategies manage vascular comorbidities improve their outcomes.