Preliminary report of clinical experience with p-aminosalicylic acid.

摘要: Although European researchers generally state that few toxic reactions, if any, result from administration of P.A.S., and it should be given in greater dosage than 15 gm. daily, our experience has been different. In this study 64.3 per cent the patients had evidence some degree toxicity. Fifteen grams day more patients, except for a very few, could tolerate when as free acid. There was fairly god tolerance on schedule 9.6 to 10.5 found therapeutically effective. On other hand 22 cases (52.4 cent) showed symptomatic benefit. Of remainder who exhibited no improvement 11.9 were asymptomatic before P.A.S. given. Perhaps greatest difference drug we employed used Europe is ours uncoated tablet acid whereas Great Britain Continent investigators sodium salt solution or enteric coated tablets We wish stress series most severe test. Eighty-eight streptomycin failures. Ninety bilateral disease. Cavities varied size less 2 cms. diameter. Cavitation present all six. 40 with pulmonary tuberculosis 42.5 mixed productive disease, definite clinical x-ray directly attributable seen 27 67.5 cent. also emphasize apparently great value endobronchial tuberculosis. Five disease previously treated unsuccessfully streptomycin; lesions healed five these cases. Two tuberculous meningitis suffered relapse subsequent six months therapy. Reinstitution treatment appeared ineffective. With addition both remission their symptoms. The drugs have discontinued three one patients. spinal fluid chemistry now approaches normal limits. All responded favorably but later relapsed, died alone used. Dunner stated resistance develops tubercie bacillus. At least clinically uphold conclusion. cases, after approximately four loss its effect observed, evidenced by increase It highly questionable, therefore, whether seek obtain combined routinely unless two are short course, perhaps longer months. desirable reserve event other. When patient being prepared surgery might preoperatively During postoperatively, especially resection, alone, streptomycin, advantageously obviate control postoperative spreads. number observed early good lost Therefore, collapse therapy necessary receiving instituted criteria will permit, may develop.