For better or worse: FFAR1 and FFAR4 signaling in cancer and diabetes

摘要: Increased energy intake can lead to obesity, which increases the risk for development of diabetes and cancer. Free fatty acids regulate numerous cellular processes, like insulin secretion, inflammation, proliferation, cell migration. Dysregulation these functions by increased lipid plays a significant role in diseases acid receptors 1 4 (FFAR1 FFAR4) are two free under increasing investigation their roles more recently also Both bind medium- long-chain, saturated omega-3 unsaturated acids. Increasing evidence shows that enhanced FFAR1 FFAR4 signaling reduces symptoms but enhances tumor growth migration various cancer types melanoma prostate This review gives an overview discusses potential function as targets treatment.