Beyond DNA repair: the novel immunological potential of PARP inhibitors.
作者： Roman M. Chabanon , Jean-Charles Soria , Christopher J. Lord , Sophie Postel-Vinay
DOI: 10.1080/23723556.2019.1585170
关键词: Immune system 、 Breast cancer 、 Cancer research 、 ERCC1 、 DNA repair 、 Polymerase 、 Nucleotide excision repair 、 Poly ADP ribose polymerase 、 Medicine 、 Lung cancer
摘要: Loss of excision repair cross-complementation group 1 (ERCC1), frequently found in lung cancer, and mutations breast cancer type 1/2 susceptibility genes (BRCA1/2), often ovarian, prostate cancers, confer sensitivity to poly-(ADP-ribose) polymerase inhibitors (PARPi). Our work, that others, shows PARPi selectively trigger tumor cell-autonomous immune phenotypes ERCC1- or BRCA-defective contexts. This suggests PARPi, used appropriately selected populations, might mediate their therapeutic effects by potentiating anti-tumor immunity.
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