Early enteral nutrition reduces mortality in trauma patients requiring intensive care: a meta-analysis of randomised controlled trials.

摘要: Abstract Introduction To determine whether the provision of early standard enteral nutrition (EN) confers treatment benefits to adult trauma patients who require intensive care. Materials and methods MEDLINE EMBASE were searched. Hand citation review retrieved guidelines systematic reviews was undertaken academic industry experts contacted. Methodologically sound randomised controlled trials (RCTs) conducted in requiring care that compared delivery EN, provided within 24 h injury, included. The primary analysis on clinically meaningful patient-oriented outcomes, which included mortality, functional status quality life. Secondary analyses considered vomiting/regurgitation, pneumonia, bacteraemia, sepsis multiple organ dysfunction syndrome. Meta-analysis using an analytical method known minimise bias presence sparse events. impact heterogeneity assessed I 2 metric. Results Three RCTs with 126 participants found be free from major flaws analysis. EN associated a significant reduction mortality (OR = 0.20, 95% confidence interval 0.04–0.91,  = 0). No other outcomes could pooled. A sensitivity confirmatory different confirmed reduction. Conclusion Although detection statistically is promising, overall trial low size small. results this meta-analysis should by conduct large multi-center trial.