Reduced toxicity and superior cellular response of preosteoblasts to Ti‐6Al‐7Nb alloy and comparison with Ti‐6Al‐4V

摘要: There are serious concerns on the toxicity of vanadium in Ti-6Al-4V alloy. In this regard, we describe biological footprint and compare with a viable alternate Ti-6Al-7Nb alloy, terms novel experimentation pertaining to cellular activity that include qualitative quantitative analysis Feret's diameter cells, area, perimeter, proteins—actin, vinculin, fibronectin. Interestingly, was characterized by superior cell attachment, proliferation, viability, morphology, spread, which were significantly different from Additionally, immunofluorescence studies demonstrated stronger vinculin signals associated actin stress fibers outer regions cells extensions These striking observations suggest enhanced cell–substrate interaction surface niobium-containing titanium The significant differences response between two alloys clearly point determining role alloying element (Nb versus V) conclusive manner. Based study, next generation is proposed focus © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.