Dysregulation of energy balance by trichothecene mycotoxins: Mechanisms and prospects.

作者: Bruno Lebrun , Catherine Tardivel , Bernadette Félix , Anne Abysique , Jean-Denis Troadec

DOI: 10.1016/J.NEURO.2015.04.009

关键词: Energy homeostasisTrichotheceneBiologyEndocrinologyMycotoxinInternal medicineFood contaminantPopulationImmune systemImmunologyChronic exposureAnorexia

摘要: Trichothecenes are toxic metabolites produced by fungi that constitute a worldwide hazard for agricultural production and both animal human health. More than 40 countries have introduced regulations or guidelines food feed contamination levels of the most prevalent trichothecene, deoxynivalenol (DON), on basis its ability to cause growth suppression. With development analytical tools, evaluation exposure revealed significant proportion population is chronically exposed DON doses exceeding provisional maximum tolerable daily dose. Accordingly, better understanding trichothecene impact health needed. Upon low moderate doses, other trichothecenes induce anorexia, vomiting reduced weight gain. Several recent studies addressed mechanisms which these symptoms multifaceted action targeting gut, liver brain causing dysregulation in neuroendocrine signaling, immune responses, hormone axis, central neurocircuitries involved energy homeostasis. Newly identified toxicosis biomarkers just beginning be exploited already open up new questions potential harmful effects chronic at apparently asymptomatic very levels. This review summarizes our current intake growth.

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