The self-assembly of redox active peptides: Synthesis and electrochemical capacitive behavior
作者： Julia P. Piccoli , Adriano Santos , Norival A. Santos-Filho , Esteban N. Lorenzón , Eduardo M. Cilli
DOI: 10.1002/BIP.22815
关键词: Redox 、 Combinatorial chemistry 、 Chemistry 、 Peptide 、 Solid-Phase Synthesis Techniques 、 Cyclic voltammetry 、 Side chain 、 Biochemistry 、 Peptide synthesis 、 Ferrocene 、 Biosensor
摘要: The present work reports on the synthesis of a redox-tagged peptide with self-assembling capability aiming applications in electrochemically active capacitive surfaces (associated presence redox centers) generally useful electroanalytical applications. Peptide containing ferrocene (fc) molecular (redox) group (Ac-Cys-Ile-Ile-Lys(fc)-Ile-Ile-COOH) was thus synthesized by solid phase (SPPS). To obtain interface, side chain cysteine covalently bound to gold electrode (sulfur group) and Lys used attach chain. After obtaining purified peptide, self-assembly characterized cyclic voltammetry (CV) electrochemical impedance-based capacitance spectroscopy techniques. obtained results confirmed that successfully attached forming an electroactive self-assembled monolayer onto electrode. design ferrocene-tagged is predictably development biosensor devices precisely detect, label-free platform, those biomarkers clinical relevance. © 2016 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 106: 357-367, 2016.
sci-hub.se 参考文章(56)
Edoardo Longo, Karen Wright, Mario Caruso, Emanuela Gatto, Antonio Palleschi, Manuela Scarselli, Maurizio De Crescenzi, Marco Crisma, Fernando Formaggio, Claudio Toniolo, Mariano Venanzi, Peptide flatlandia: a new-concept peptide for positioning of electroactive probes in proximity to a metal surface Nanoscale. ,vol. 7, pp. 15495- 15506 ,(2015) , 10.1039/C5NR03549J
Christina Boozer, Shengfu Chen, Shaoyi Jiang, Controlling DNA orientation on mixed ssDNA/OEG SAMs. Langmuir. ,vol. 22, pp. 4694- 4698 ,(2006) , 10.1021/LA052908E
Maggie Paulose, Karthik Shankar, Oomman K Varghese, Gopal K Mor, Craig A Grimes, Application of highly-ordered TiO2 nanotube-arrays in heterojunction dye-sensitized solar cells Journal of Physics D. ,vol. 39, pp. 2498- 2503 ,(2006) , 10.1088/0022-3727/39/12/005
Paulo R. Bueno, Jason J. Davis, Elucidating Redox-Level Dispersion and Local Dielectric Effects within Electroactive Molecular Films web science. ,vol. 86, pp. 1997- 2004 ,(2014) , 10.1021/AC4031708
Dindyal Mandal, Amir Nasrolahi Shirazi, Keykavous Parang, None, Self-assembly of peptides to nanostructures Organic and Biomolecular Chemistry. ,vol. 12, pp. 3544- 3561 ,(2014) , 10.1039/C4OB00447G
Adriano Santos, Fernanda C. Carvalho, Maria-Cristina Roque-Barreira, Paulo R. Bueno, Impedance-derived electrochemical capacitance spectroscopy for the evaluation of lectin-glycoprotein binding affinity. Biosensors and Bioelectronics. ,vol. 62, pp. 102- 105 ,(2014) , 10.1016/J.BIOS.2014.06.034
Emanuela Gatto, Mariano Venanzi, Self-assembled monolayers formed by helical peptide building blocks : a new tool for bioinspired nanotechnology Polymer Journal. ,vol. 45, pp. 468- 480 ,(2013) , 10.1038/PJ.2013.27
J.-M. Lehn, Toward complex matter: supramolecular chemistry and self-organization. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 4763- 4768 ,(2002) , 10.1073/PNAS.072065599
D. Wade, A. Boman, B. Wahlin, C. M. Drain, D. Andreu, H. G. Boman, R. B. Merrifield, All-D amino acid-containing channel-forming antibiotic peptides. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 4761- 4765 ,(1990) , 10.1073/PNAS.87.12.4761
S. Trasatti, O. A. Petrii, Real surface area measurements in electrochemistry Pure and Applied Chemistry. ,vol. 63, pp. 711- 734 ,(1991) , 10.1351/PAC199163050711