BioCAST/IFCT-1002: epidemiological and molecular features of lung cancer in never-smokers.
作者： Sébastien Couraud , Pierre-Jean Souquet , Christophe Paris , Pascal Dô , Hélène Doubre
DOI: 10.1183/09031936.00097214
关键词: Pathological 、 KRAS 、 Observational study 、 Risk factor 、 Epidemiology 、 Surgery 、 Biomarker (medicine) 、 Passive smoking 、 Lung cancer 、 Internal medicine 、 Medicine
摘要: Lung cancer in never-smokers (LCINS) (fewer than 100 cigarettes lifetime) is considered as a distinct entity and harbours an original molecular profile. However, the epidemiological features of LCINS Europe remain poorly understood. All consecutive newly diagnosed patients were included this prospective observational study by 75 participating centres during 14-month period. Each patient completed detailed questionnaire about risk factor exposure. Biomarker pathological analyses also collected. We report main descriptive overall results with focus on sex differences. 384 included: 65 men 319 women. 66% had been exposed to passive smoking (significantly higher among women). Definite exposure occupational carcinogens was significantly (35% versus 8% A targetable alteration found 73% (without any significant difference): EGFR 51%, ALK 8%, KRAS 6%, HER2 3%, BRAF PI3KCA less 1%, multiple 2%. We present largest most comprehensive analysis European population. Physicians should track (35%), somatic both sexes (73%). Occupational mutation be tracked lung never-smokers.
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