Modified atherogenic lipoproteins induce expression of pentraxin-3 by human vascular smooth muscle cells
作者： Mariam Klouche , Giuseppe Peri , Cornelius Knabbe , Hanns-Henning Eckstein , Franz-Xaver Schmid
DOI: 10.1016/J.ATHEROSCLEROSIS.2004.03.020
关键词: Vascular smooth muscle 、 Messenger RNA 、 Pathogenesis 、 Acute-phase protein 、 PTX3 、 Cholesterol 、 Inflammation 、 Internal medicine 、 Foam cell 、 Biology 、 Endocrinology
摘要: Inflammation is a critical contributing factor to the development and progression of atherosclerosis. Recently, acute-phase protein pentraxin-3 (PTX3), which has C-terminal sequence homology with classic pentraxin C-reactive (CRP), was described be increased in patients myocardial infarction. In this study, we have investigated capacity human primary vascular smooth muscle cells (VSMC), derived from arterial specimens ten different patients, express PTX3 after incubation atherogenic lipoproteins. Enzymatically degraded LDL (E-LDL), present early lesions, mediated rapid cholesterol loading foam cell transformation VSMC, paralleled by marked dose- time-dependent expression mRNA release protein. Expression delayed remained almost undetectable for up 6 h E-LDL. However, during extended exposure E-LDL more than 24 h, 15-fold VSMC cells, reflected concomitant 211 ng/ml We provide evidence induced lipoproteins, may lead an situ reaction, inflammatory pathogenesis
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