The effects of cell compressibility, motility and contact inhibition on the growth of tumor cell clusters using the Cellular Potts Model

摘要: There are numerous biological examples where genes associated with migratory ability of cells also confer the an increased fitness even though these may not have any known effect on cell mitosis rates. Here, we provide insight into observations by analyzing effects migration, compression, and contact inhibition growth tumor clusters using Cellular Potts Model (CPM) in a monolayer geometry. This is follow-up previous study (Thalhauser et al. 2010) which Moran-type model was used to interaction proliferation, potential death emergence invasive phenotypes. extend include size shape. In particular, investigate interplay between motility compressibility within CPM find that predicts leads smaller cells. artifact CPM. An analysis reveals explicit inverse-relationship stiffness parameters. We use this relationship compensate for motility-induced changes so corrected CPM, independent motility. subject comparable levels motile grow faster than less cells, qualitative agreement our study. Increasing compression tends reduce Contact penalizes clumped halting their gives greater advantage. Finally, distributions consistent those observed neuroblastoma cultured low high density conditions.