Altered default mode network connectivity in older adults with cognitive complaints and amnestic mild cognitive impairment.
作者： Yang Wang , Shannon L. Risacher , John D. West , Brenna C. McDonald , Tamiko R. MaGee
DOI: 10.3233/JAD-130080
关键词: Audiology 、 Effects of sleep deprivation on cognitive performance 、 Neuroscience 、 Amnesia 、 Neuropsychology 、 Default mode network 、 Atrophy 、 Psychology 、 Hippocampus 、 Cognitive impairment 、 Cognition
摘要: Default mode network (DMN) disruption has been reported in Alzheimer's disease (AD), yet the specific pattern of altered connectivity over course prodromal AD remains to be characterized. The aim this study was assess DMN older adults with informant-verified cognitive complaints (CC) but normal neuropsychological performance compared individuals mild impairment (MCI) and healthy controls (HC). maps were derived from resting-state fMRI using independent component analysis. Group comparisons performed between MCI (n = 18), CC 23), HC 16). Both showed decreased right hippocampus HC, group showing greater than MCI. These differences survived atrophy correction correlated performance. appears sensitive early neurodegenerative changes associated AD, notably including pre-MCI complaints.
sci-hub.se 参考文章(46)
Brent A. Vogt, Steven Laureys, Posterior cingulate, precuneal and retrosplenial cortices: cytology and components of the neural network correlates of consciousness. Progress in Brain Research. ,vol. 150, pp. 205- 217 ,(2005) , 10.1016/S0079-6123(05)50015-3
M. D. Fox, A. Z. Snyder, J. L. Vincent, M. Corbetta, D. C. Van Essen, M. E. Raichle, The human brain is intrinsically organized into dynamic, anticorrelated functional networks Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 9673- 9678 ,(2005) , 10.1073/PNAS.0504136102
Marshal F. Folstein, Susan E. Folstein, Paul R. McHugh, “Mini-mental state” Journal of Psychiatric Research. ,vol. 12, pp. 189- 198 ,(1975) , 10.1016/0022-3956(75)90026-6
David T. Jones, Farrah J. Mateen, Claudia F. Lucchinetti, Clifford R. Jack, Kirk M. Welker, Default mode network disruption secondary to a lesion in the anterior thalamus. JAMA Neurology. ,vol. 68, pp. 242- 247 ,(2011) , 10.1001/ARCHNEUROL.2010.259
Brittany R. Copenhaver, Laura A. Rabin, Andrew J. Saykin, Robert M. Roth, Heather A. Wishart, Laura A. Flashman, Robert B. Santulli, Tara L. McHugh, Alexander C. Mamourian, The fornix and mammillary bodies in older adults with Alzheimer's disease, mild cognitive impairment, and cognitive complaints: a volumetric MRI study. Psychiatry Research-neuroimaging. ,vol. 147, pp. 93- 103 ,(2006) , 10.1016/J.PSCYCHRESNS.2006.01.015
T. Gili, M. Cercignani, L. Serra, R. Perri, F. Giove, B. Maraviglia, C. Caltagirone, M. Bozzali, Regional brain atrophy and functional disconnection across Alzheimer's disease evolution Journal of Neurology, Neurosurgery, and Psychiatry. ,vol. 82, pp. 58- 66 ,(2011) , 10.1136/JNNP.2009.199935
E. T. Westlye, A. Lundervold, H. Rootwelt, A. J. Lundervold, L. T. Westlye, Increased hippocampal default mode synchronization during rest in middle-aged and elderly APOE ε4 carriers: relationships with memory performance. The Journal of Neuroscience. ,vol. 31, pp. 7775- 7783 ,(2011) , 10.1523/JNEUROSCI.1230-11.2011
Frank Jessen, Ludger Feyen, Katrin Freymann, Ralf Tepest, Wolfgang Maier, Reinhard Heun, Hans-H. Schild, Lukas Scheef, Volume reduction of the entorhinal cortex in subjective memory impairment. Neurobiology of Aging. ,vol. 27, pp. 1751- 1756 ,(2006) , 10.1016/J.NEUROBIOLAGING.2005.10.010
Reisa A. Sperling, Peter S. LaViolette, Kelly O'Keefe, Jacqueline O'Brien, Dorene M. Rentz, Maija Pihlajamaki, Gad Marshall, Bradley T. Hyman, Dennis J. Selkoe, Trey Hedden, Randy L. Buckner, J. Alex Becker, Keith A. Johnson, Amyloid deposition is associated with impaired default network function in older persons without dementia Neuron. ,vol. 63, pp. 178- 188 ,(2009) , 10.1016/J.NEURON.2009.07.003
Bruce Fischl, David H. Salat, Evelina Busa, Marilyn Albert, Megan Dieterich, Christian Haselgrove, Andre van der Kouwe, Ron Killiany, David Kennedy, Shuna Klaveness, Albert Montillo, Nikos Makris, Bruce Rosen, Anders M. Dale, Whole Brain Segmentation Neuron. ,vol. 33, pp. 341- 355 ,(2002) , 10.1016/S0896-6273(02)00569-X