Variable Virulence Factors in Burkholderia pseudomallei (Melioidosis) Associated with Human Disease

摘要: Burkholderia pseudomallei is a Gram-negative environmental bacterium that causes melioidosis, potentially life-threatening infectious disease affecting mammals, including humans. Melioidosis symptoms are both protean and diverse, ranging from mild, localized skin infections to more severe often fatal presentations pneumonia, septic shock with multiple internal abscesses occasionally neurological involvement. Several ubiquitous virulence determinants in B. have already been discovered. However, the molecular basis for differential pathogenesis has, until now, remained elusive. Using clinical data 556 Australian melioidosis cases spanning than 20 years, we identified mallei-like actin polymerization bimABm gene strongly associated disease. We also report filamentous hemagglutinin gene, fhaB3, positive blood cultures but negatively correlated lesions without sepsis. show, first time, variably present factors play an important role of melioidosis. Collectively, our study provides framework assessing other non-ubiquitous bacterial their association disease, such as candidate loci large-scale microbial genome-wide studies.