Acute changes in high energy phosphates, nucleotide derivatives, and contractile force in ischaemic and nonischaemic canine myocardium following coronary occlusion

作者： C. E. JONES , J. X. THOMAS , J. C. PARKER , R. E. PARKER

关键词: Nucleotide 、 Muscle contraction 、 Adenosine triphosphate 、 Adenine nucleotide 、 Coronary occlusion 、 Chemistry 、 Creatine 、 Ischemia 、 Internal medicine 、 Phosphocreatine 、 Cardiology

摘要: Studies of ischaemic myocardium following occlusion coronary arterial branches revealed a substantial decline in creatine phosphate, adenosine triphosphate, and total adenine nucleotide contents over 40 min. Contents breakdown derivatives increased significantly but transiently. Contractile force declined rapidly stabilized at low level. In nonischaemic muscle rapidly, although not to the degree seen muscle. only slightly. increased.