Pathology of experimental pneumonic plague produced by fraction 1-positive and fraction 1-negative Yersinia pestis in African green monkeys (Cercopithecus aethiops).

摘要: . Objective.-The protein capsule of Yersinia pestis, known as Fraction 1 or F1, is a protective immunogen and an assumed, but not proven, virulence factor. Our objectives were to determine if inhaled F1-negative and/or F1-positive strains Y pestis virulent in the African green monkey and, so, differentiate from monkeys. Because have been isolated natural sources caused experimental fatal disease, we felt that this information was crucial development future vaccines diagnostic tests. Materials Methods.-Adult monkeys exposed by aerosol (CO92, n = 15) (C092-C12, 6 ; Java-9, 2) strains. Results.-All died 4 10 days postexposure had lesions consistent with primary pneumonic plague. Antibodies F1 antigen other antigens allowed us fixed tissues. Conclusions.-In study, required Therefore, there may be need for assays are solely based on antigen.