Long-term outcomes and role of chemotherapy in adults with newly diagnosed medulloblastoma.

摘要: OBJECTIVE:: To assess the survival and role of adjuvant chemotherapy in adult medulloblastoma. METHODS:: We reviewed outcomes 66 patients (aged 18 y or more; median age, 33 y) with Forty-four (67%) had M0 disease, 9 M1-M4, 13 MX. Thirty-one each for whom risk stratification was available were classified as high standard risk. Fifty-six histologic results: classic histology most common [n=46 (84%)], followed by desmoplastic (n=9), large cell/anaplastic (n=1). Overall (OS) progression-free (PFS) estimated Kaplan-Meier curves log-rank tests. Cox regression analysis used to compare recurrences. RESULTS:: Median follow-up 6.7 years. The 5-year OS PFS 74% 59%, respectively. High-risk versus standard-risk classification ass ociated worse (61% vs. 86%; P=0.03) recurrence (hazard ratio, 2.56; P=0.05) a tren d (49% 69%; P=0.13). Gross total resection associated improved (P=0.03) trend toward (P=0.09). No benefit could be demonstrated group whole. For high-risk (n=25), improvement from 36% 71% (P=0.10) 49% 100% (P=0.08). CONCLUSIONS:: In medulloblastoma, extent predicts outcome. These results suggest histology. PMID: 23111362 [PubMed - supplied publisher]